DOI: https://doi.org/10.61435/jbes.2024.19935

Efficacy of Tribulus terrestris on diabetes and sexual disorders: A narrative review

1Environmental Biomonitoring laboratory LBE (LR01/ES14), Faculty of Science of Bizerta. Carthage University Tunisia, Tunisia

2Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

Received: 28 Mar 2024; Revised: 13 Apr 2024; Accepted: 7 May 2024; Available online: 15 May 2024; Published: 1 Dec 2024.
Editor(s): H. Hadiyanto
Open Access Copyright (c) 2024 The Author(s). Published by Centre of Biomass and Renewable Energy (CBIORE)
Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

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Abstract

Tribulus terrestris L. (T. terrestris) is widely distributed worldwide (Australia, Europe, India, North Africa). It typically contains a substantial amount of active ingredients, especially saponins, alkaloids, flavonoids, tannins, terpenoids, and phenol carboxylic acids. Additionally, T. terrestris has been frequently used in folk medicine and as a food supplement, highlighting the importance of evaluating its phytopharmacological properties. Various hypotheses suggest that this species may have significant potential in preventing and improving various human conditions, including diabetes, inflammatory diseases, low sexual desire, and infertility. Phytochemical studies reveal a significant disparity in the content of active substances, with a notable gap in the concentrations of spirostanol saponins and furostanol, which are the predominant active ingredients associated with therapeutic effects. The objective of this present review is to evaluate T. terrestris -based formulations by exploring various potential mechanisms of action, aiming to determine whether the use of T. terrestris supplements is justified in the context of diabetes and its complications.

 

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Keywords: Steroidal saponins; Diabetes; Erectile dysfunction; nutraceuticals

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