1Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, PO Box 2701, Cameroon
2Laboratory of Pharmacology and toxicology, Doctoral Training Unit of Health Sciences, university of Douala, PO Box 2701, Cameroon
3Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbrücken, Germany
4 Department of Animal Biology and Physiology, Faculty of Science, University of Douala, PO Box 24157 Douala, Cameroon
5 Biology and Physiology Laboratory of Plant Sciences, Faculty of Sciences, University of Douala, PO Box. 24157 Douala, Cameroon
6 Laboratory of Pharmacochemistry and Natural Pharmaceutical Substances, Doctoral Training Unit of Health Sciences, University of Douala, PO Box 2701, Cameroon
BibTex Citation Data :
@article{JBES19919, author = {Francois Eya'ane Meva and Ludrice Djomaha and Muhammad Nasim and Agnes Ntoumba and Armelle Kouemegne and Patrice Ottou and Gisele Loe and Siegfried Dibong and Claus Jacob}, title = {Bead milling liberates the antioxidant properties of nanosized tubers of Vernonia guineensis Benth (Asteraceae)}, journal = {Journal of Bioresources and Environmental Sciences}, volume = {3}, number = {1}, year = {2024}, keywords = {Vernonia guineensis Benth.; ball milling; colloids; antioxidant activity}, abstract = { Vernonia guineensis Benth. (Asteraceae), locally known as ‘African ginseng’, is an herbaceous plant with various therapeutic properties, sold by herbalists, and used in several traditional African preparations. Nanosizing has the capability to potentiate those preparations in their pharmacological properties. Premilling and extensive grinding using a planetary ball mill were used to reduce the size of V. guineensis tubers towards antioxidant studies. Water was used as an environmental friendly, cost effective solvent and dispersant to generate a nanocolloidal suspension of V. guineensis tubers. Size and size distribution were determined via photon correlation spectroscopy at room temperature which allows discussion on stability by Zeta potential and polydispersity index. Phytochemical screening shows presence of alkaloids, coumarins, polyphenol, saponins, tanins, terpenes, and anthraquinones. The distribution curve in water shows a polydispersed system with large hydrodynamic particles of size close to 1000 nm and a Z-average of 484.5 nm. The preparation separate in two phases with polydispersity index 0.217 for the supernatant and 0.543 for the suspension. In the supernatant and suspension, the particles zeta potential were -12.3 mV and -13.7mV respectively. The Mastersizer analysis indicates that there are smaller particles in volume in the supernatant than in the suspension. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity shows an increase in antioxidant activity, compared to that of ascorbic acid, in the nanoformulated state. These findings allow us to conclude on the potential of size reduction when compared to solvent extraction in pharmacologic preparations. }, issn = {2829-7741}, pages = {14--26} doi = {10.61435/jbes.2024.19919}, url = {https://jbes.cbiore.id/index.php/jbes/article/view/19919} }
Refworks Citation Data :
Vernonia guineensis Benth. (Asteraceae), locally known as ‘African ginseng’, is an herbaceous plant with various therapeutic properties, sold by herbalists, and used in several traditional African preparations. Nanosizing has the capability to potentiate those preparations in their pharmacological properties. Premilling and extensive grinding using a planetary ball mill were used to reduce the size of V. guineensis tubers towards antioxidant studies. Water was used as an environmental friendly, cost effective solvent and dispersant to generate a nanocolloidal suspension of V. guineensis tubers. Size and size distribution were determined via photon correlation spectroscopy at room temperature which allows discussion on stability by Zeta potential and polydispersity index. Phytochemical screening shows presence of alkaloids, coumarins, polyphenol, saponins, tanins, terpenes, and anthraquinones. The distribution curve in water shows a polydispersed system with large hydrodynamic particles of size close to 1000 nm and a Z-average of 484.5 nm. The preparation separate in two phases with polydispersity index 0.217 for the supernatant and 0.543 for the suspension. In the supernatant and suspension, the particles zeta potential were -12.3 mV and -13.7mV respectively. The Mastersizer analysis indicates that there are smaller particles in volume in the supernatant than in the suspension. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity shows an increase in antioxidant activity, compared to that of ascorbic acid, in the nanoformulated state. These findings allow us to conclude on the potential of size reduction when compared to solvent extraction in pharmacologic preparations.
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